Nutrition and PI3K/Akt signaling are required for p38-dependent regeneration

ABSTRACT Regeneration after damage requires early signals to trigger the tissue repair machinery. Reactive oxygen species (ROS) act as that are sensed by MAP3 kinase Ask1, which in turn activates phosphorylation MAP kinases p38 and JNK. The sustained or high activation of these can result apoptosis, whereas short low promote regeneration. Using Ask1-dependent regeneration program, we demonstrate Drosophila wing PI3K/Akt signaling is necessary for Ask1 activate p38, but not In addition, nutrient restriction mutations target Ser83 protein, a PI3K/Akt-sensitive residue, block However, effects be reversed ectopic Our results controls through Ser83, during sensitive. This mechanism important discriminating between JNK cells involved regenerative growth.